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. 2021 Jul 15;64(15):10849–10877. doi: 10.1021/acs.jmedchem.0c02274

Figure 2.

Figure 2

(a) Binding mode of the co-crystallized ligand GSK650394 in the ATP-binding site of CAMKK2 (PDB-ID: 6BKU). The image was generated with PyMOL. The protein is colored in gray. Blue-dashed lines indicate H-bond interactions; green-dashed lines display CH−π interactions. GSK650394 is shown as purple sticks and the water molecule as a red sphere. Oxygen and nitrogen atoms are colored in red and blue, respectively. (b) Structure of GSK650394 highlighting important sites for design of new CAMKK2 inhibitors.