Scheme 1. Synthesis of Pinacol Boronate Esters 3 and 4.
Reagents and conditions: (a) cyclopentylmagnesium bromide, THF, −10 to 25 °C, 5 h, then aq HCl; (b) PdCl2(dppf)·CH2Cl2, KOAc, bis(pinacolato)diboron, 100 °C, 2 h; (c) SOCl2, MeOH, 16 h, 75 °C.
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