Table 4. CAMKK2 Enzyme Inhibition Data for Substituted Pyrimidines and 4-Aminopyrimidines^a.

^aR = ortho-cyclopentyl benzoic acid moiety; PoC (percent of control = percent of enzyme activity remaining, when compared with the control); IC₅₀ (half-maximal inhibitory concentration); NG (not generated); IC₅₀ values were generated in an 8-point full dose response assay.