TABLE 1.
Summary of hypothalamic anorexigenic and orexigenic neuropeptides in Prader‐Willi Syndrome
| Neuropeptide | CNS | Hypoactivity/Hyperactivity | Plasma concentrations |
Reference (##) |
|---|---|---|---|---|
| NPY | Decreased expression and cell count | Hypoactivity | – | 103 |
| AgRP | Decreased expression and unchanged cell count | Hypoactivity | – | 103, 121 |
| Hypocretin | Unchanged cell count | Unaltered/ Hyperactivity (?) | Increased | 130, 131 |
| POMC | Decreased expression | Hypoactivity | – | 121 |
| OXT | Decreased expression and cell count | Hypoactivity | Increased | 102, 142 |
| BDNF | Decreased expression | Hypoactivity | Decreased | 121, 146 |
Abbreviations: AgRP, agouti related protein; BDNF, brain derived neurotrophic factor; NPY, Neuropeptide Y; OXT, oxytocin; POMC, proopiomelanocortin.