TABLE 1.
Epidemiological weight of SIRD‐associated uveitides among the causes of uveitis in different cohorts of patients worldwide
| Percentage distribution of uveitis by associated SIRDs worldwide | |||||||
|---|---|---|---|---|---|---|---|
| Disease |
Australia13 (%) (n = 1236) |
Italy8 (%) (n = 1064) |
France7 (%) (n = 912) |
China9 (%) (n = 823) |
Japan10 (%) (n = 750) |
United States12 (%) (n = 491) |
Tunisia11 (%) (n = 472) |
| Behçet's disease | 1.8% | 5.3% | 8.2% | 2.8% | 4.4% | n.a | 12.2% |
| Ankylosing spondylitis | 3.6% | n.a | n.a | 5.8% | n.a | 1% | 1.7% |
| IBD‐related spondyloarthropathies | 0.6% | n.a | n.a | n.a | n.a | 1.2% | 0.8% |
| Psoriatic arthritis | 0.1% | n.a | n.a | 1.1% | n.a | 0.2% | 0.8% |
| Reactive arthritis | 0.3% | n.a | n.a | n.a | n.a | 0.2% | 0.2% |
| Sarcoidosis | 3.5% | 2.5% | 17.1% | 1.4% | 6.1% | 6.7% | 1.7% |
| Vogt‐Koyanagi‐Harada syndromea | n.a | 2% | 2.6% | n.a | 4.1% | n.a | n.a |
| Rheumatoid arthritis | 0.3% | n.a | n.a | 0.003% | 0.2% | n.a | 0.2% |
| Juvenile idiopathic arthritis | 0.6% | n.a | n.a | 1.1% | 0.2% | n.a | 0.6% |
| Idiopathic | 60.2% | 26% | 46.9% | n.a | 40.7% | 32.2% | 35.2% |
| HLA‐B27‐associated uveitisb | 11.2% | 5.3% | 16.7% | n.a | 1.8% | 6.7% | 1% |
| Othersc | 17.8% | 58.9% | 8.5% | 87.8% | 42.5% | 51.8% | 45.6% |
Abbreviations: HLA‐B27, human leucocyte antigen B27; IBD, inflammatory bowel disease; n.a, Not assessed; SIRDs, systemic inflammatory rheumatic diseases.
Vogt‐Koyanagi‐Harada disease was included in the list because of its immune‐mediated origin despite not being a rheumatologic condition.
In some studies, the seronegative spondyloarthropathy underlying HLA‐B27 positivity was not specified and patients were classified as generally affected by ‘HLA‐B27 associated uveitis’.
Including infectious, immune‐mediated, neoplastic, drug‐related and post‐surgical causes.