TABLE 3.

Clearance of LMW PRIs during cation exchange chromatography

LMW PRIs	Concentration in load (μg/ml)	Concentration in flow‐through (μg/ml)	Concentration in eluate (μg/ml)
BME	869	651	<1
Dextran sulfate	643	330	45.6
EDTA	615	508	<0.5
Polysaccharide	0.47	0.45	0.0006
MTG	661	520	<0.8
MSX	68	56	<0.01
PEG8000	16,797	12,539	<20
Simethicone	240	220	<1.3
Triton X‐100	9,885	5,622	94.2
Tropolone	312	211	<1.8