Table 1.
Secondary outcome measures of the trial (in alphabetical order)
| Scale name | Assessor | Construct | Author | Italian version | Timing |
| 4-item ACP-E | Patient | ACP engagement | Sudore et al31 | – | T0/T1/T2 |
| eCPS | Patient | Role preferences | Degner et al40 | Solari et al42 | T0 |
| HADS | Patient | Mood symptoms | Zigmond and Snaith44 | Costantini et al36 | T0/T1/T2 |
| MSQOL-29 | Patient | Health-related QOL | Rosato et al38 | Rosato et al38 | T0/T2 |
| OPTION | Third observer | Shared Decision Making (physician’s kills) | Elwyn et al43 | Goss et al37 | – |
| QOC | Patient | Communication quality (physician’s skills) | Engelberg et al32 | – | T1 |
| QOC-Doc | Physician | Communication quality (physician’s skills) | – | – | T1 |
| QOC-SO | SO | Communication quality (physician’s skills) | – | – | T1 |
| ZBI | SO | Caregiver burden | Hérbert et al46 | Chattat et al39 | T0/T1/T2 |
ACP-E, Advance Care Planning Engagement; eCPS, Control Preference Scale, electronic; HADS, Hospital Anxiety and Depression Scale; MSQOL-29, 29-item Multiple Sclerosis Quality of Life; OPTION, Observing Patient Involvement in Shared Decision Making; QOC, Quality of Communication; SO, significant other; ZBI, Zarit Burden Interview.