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. 2021 Aug 13;9(8):e003180. doi: 10.1136/jitc-2021-003180

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© Author(s) (or their employer(s)) 2021. Re-use permitted under CC BY. Published by BMJ.

This is an open access article distributed in accordance with the Creative Commons Attribution 4.0 Unported (CC BY 4.0) license, which permits others to copy, redistribute, remix, transform and build upon this work for any purpose, provided the original work is properly cited, a link to the licence is given, and indication of whether changes were made. See https://creativecommons.org/licenses/by/4.0/.

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rSmeg-hMIF-hIL-7 inhibited the infiltration of myeloid-derived suppressor cells (MDSCs) into the tumor environment. (A) The population of total MDSC, monocytic MDSC and granulocytic MDSC in mice tumor tissue 4 days after the last mycobacteria injection. Surface expression levels of MIF receptors CXCR2, CXCR4, and CXCR7 of (B) M-MDSC and (C) G-MDSC were detected by flow cytometry. The population of IL-10-releasing (D) M-MDSC and G-MDSC in tumors were analyzed by flow cytometry. Significance differences (*p<0.05, **p<0.01, and ***p<0.001) among the different groups are shown in the related figures, and the data are presented as the mean±SEM of mice (n=5).