Recommendation	Grade	Level of evidence	Key references
1.1	Use objective hemodynamic tests to determine the presence and to quantify the severity of ischemia in all patients with suspected CLTI.	1 (Strong)	C (Low)	de Graaff,16 2003 Brownrigg,17 2016 Wang,18 2016
1.2	Use a lower extremity threatened limb classification staging system (eg, SVS’s WIfI classification system) that grades wound extent, degree of ischemia, and severity of infection to guide clinical management in all patients with suspected CLTI.	1 (Strong)	C (Low)	See Table 1.2