| Recommendations | Grade | Level of evidence | Key references | |
|---|---|---|---|---|
|
| ||||
| 4.9 | Consider control of type 2 DM in CLTI patients to achieve a hemoglobin A1c of <7% (53 mmol/mol [International Federation of Clinical Chemistry]). | 2 (Weak) | B (Moderate) | Selvin,49 2004 Nathan,50 2005 van Dieren,51 2014 Fox,52 2015 American Diabetes Association,53 2018 |
| 4.10 | Use metformin as the primary hypoglycemic agent in patients with type 2 DM and CLTI. | 1 (Strong) | A (High) | Palmer,54 2016 |
| 4.11 | Consider withholding metformin immediately before and for 24 to 48 hours after the administration of an iodinated contrast agent for diabetic patients, especially those with an estimated glomerular filtration rate <30 mL/min/1.73 m2. | 2 (Weak) | C (Low) | Nawaz,55 1998 Goergen,56 2010 Stacul,57 2011 |
Official websites use .gov
A
.gov website belongs to an official
government organization in the United States.
Secure .gov websites use HTTPS
A lock (
) or https:// means you've safely
connected to the .gov website. Share sensitive
information only on official, secure websites.