Research priorities
2.1	Quantify and track the incidence, prevalence, demographics, and risk factors associated with CLTI in different global regions.
2.2	Describe the contemporary natural history of CLTI (including risk to the limb, cardiovascular events, and all-cause mortality in that population) in different global regions.
2.3	Describe the contemporary management strategies used in the treatment of CLTI around the world and the associated outcomes.
2.4	Describe and monitor the incidence and prevalence of nontraumatic lower limb amputation around the globe (eg, the Global Amputation Study, https://GAS.vascunet.org).
2.5	Establish a reliable system to monitor the number of major amputations in as many countries and regions as possible. Time trends and differences around the globe could then be studied.