SLE |
Systemic lupus erythematosus |
miRNAs |
microRNAs |
auto-Abs |
autoantibodies |
DCs |
dendritic cells |
TLR |
Toll-like receptor |
NF-κB |
nuclear factor kappa-light-chain-enhancer of activated B cells |
pri-miRNAs |
primary RNA transcripts |
RNase III enzyme |
ribonuclease III enzyme |
pre-miRNA |
precursor miRNAs |
RISC |
RNA-induced silencing complex |
mRNA |
messenger RNA |
3’-UTR |
3’-untranslated region |
mDC |
myeloid DC |
pDC |
plasmacytoid DC |
Blimp1 |
B lymphocyte–induced maturation protein-1 |
SOCS |
suppressor of cytokine signaling |
SHIP-1 |
SH2 domain-containing inositol 5’-phosphatase 1 |
JAK-STAT |
Janus kinase/signal transducer and activator of transcription |
PI3K |
phosphatidylinositol 3-kinase |
AKT |
protein kinase B |
BCR |
B cell receptor |
LYN |
Lck/Yes novel tyrosine kinase |
FcγRIIb |
Fcγ receptor IIb |
PTEN |
phosphatase and tensin homolog |
Bcl-2 |
B cell lymphoma-2 |
EBF1 |
expression of Early B cell factor 1 |
Tfh cells |
follicular helper T cells |
DNMTs |
DNA methyltransferases |
RASGRP1 |
rasguanyl-nucleotide-releasingprotein1 |
TNFSF |
tumour necrosis factor superfamily |
LAF-1 |
lymphocyte function-associated antigen 1 |
SLAM |
signaling lymphocytic activation molecule |
IL-10 |
interleukin 10 |
SAP |
SLAM associated protein |
IgG |
immunoglobulin G |
STAT-1 |
activator of transcription-1 |
API5 |
apoptosis inhibitory protein 5 |
Foxp3 |
forkhead box P3 |
Teff cell |
effector T cell |
Treg cells |
regulatory T cells |
PBMCs |
peripheral blood mononuclear cells |
TNF α |
tumour necrosis factor α |
cAMP |
cyclic adenosine monophosphate |
Th cell |
T helper cell |
IFN-1 |
type 1 interferon |
MHC I |
major histocompatibility complex I |
CXCL |
chemokine (C-X-C motif) ligand |
CXCR 3 |
CXC chemokine receptors 3 |
APCs |
antigen-presenting cells |
RANTES |
regulated on activation, normal T cell expressed and secreted |