Table 3.
Analysis of genotypic association of SNPs in 3' UTR of CORIN with essential hypertension under different genetic inheritance models.
| SNP | Model | Without adjustment | With adjustment | ||
|---|---|---|---|---|---|
| Pobs | OR (95% CI) | Padj | OR (95% CI) | ||
| rs3749585 | Dominant | 3.30E-04 | 1.322 (1.135–1.540) | 0.015 | 1.233 (1.042–1.459) |
| Recessive | 0.878 | 1.013 (0.860–1.193) | 0.492 | 1.065 (0.889–1.276) | |
| Additive | 0.017 | 1.123 (1.021–1.236) | 0.050 | 1.112 (1.000–1.237) | |
| rs4695253 | Dominant | 0.088 | 1.146 (0.980–1.340) | 0.218 | 1.115 (0.938–1.325) |
| Recessive | 0.008 | 1.880 (1.181–2.994) | 0.005 | 2.084 (1.246–3.488) | |
| Additive | 0.021 | 1.176 (1.024–1.349) | 0.054 | 1.161 (0.998–1.352) | |
| rs12641823 | Dominant | 0.355 | 0.930 (0.798–1.805) | 0.499 | 0.943 (0.796–1.118) |
| Recessive | 0.708 | 1.033 (0.871–1.225) | 0.470 | 1.072 (0.88–1.293) | |
| Additive | 0.707 | 0.981 (0.889–1.083) | 0.989 | 0.999 (0.896–1.114) | |
SNP, single-nucleotide polymorphism; 3'UTR, 3 untranslated region; OR, odds ratio; CI, confidential interval; Padj, P-value for association after adjusting for covariates sex and age by multiple logistic regression analysis using SPSS version 22.0; Pobs, P-value for association before adjusting for covariates age and sex by 2 × 2 contingence tables using PLINK version 1.07. The bold values mean P < 0.05.