Table 4.
Analysis of genotypic association of SNPs in 3' UTR of CORIN with AF, HF, and CAD under different genetic inheritance models.
| Disease | SNP | Model | Without adjustment | With adjustment | ||
|---|---|---|---|---|---|---|
| Pobs | OR (95% CI) | Padj | OR (95% CI) | |||
| AF | rs3749585 | Dominant | 0.196 | 0.881 (0.728–1.067) | 0.009 | 0.762 (0.621–0.935) |
| Recessive | 0.422 | 0.916 (0.738–1.136) | 0.584 | 0.938 (0.746–1.179) | ||
| Additive | 0.196 | 0.921 (0.814–1.043) | 0.048 | 0.873 (0.763–0.999) | ||
| rs4695253 | Dominant | 0.479 | 1.075 (0.879–1.315) | 0.834 | 1.023 (0.826–1.267) | |
| Recessive | 0.129 | 1.517 (0.885–2.600) | 0.264 | 1.390 (0.780–2.474) | ||
| Additive | 0.281 | 1.101 (0.924–1.312) | 0.599 | 1.051 (0.873–1.266) | ||
| rs12641823 | Dominant | 0.391 | 0.917 (0.753–1.117) | 0.585 | 0.943 (0.765–1.164) | |
| Recessive | 0.192 | 0.860 (0.685–1.079) | 0.240 | 0.866 (0.680–1.101) | ||
| Additive | 0.193 | 0.918 (0.808–1.044) | 0.305 | 0.931 (0.813–1.067) | ||
| HF | rs3749585 | Dominant | 0.113 | 1.201 (0.957–1.506) | 0.110 | 1.252 (0.951–1.648) |
| Recessive | 0.993 | 0.999 (0.786–1.269) | 0.478 | 1.111 (0.831–1.486) | ||
| Additive | 0.315 | 1.074 (0.934–1.235) | 0.150 | 1.135 (0.955–1.349) | ||
| rs4695253 | Dominant | 0.019 | 1.304 (1.046–1.627) | 0.068 | 1.286 (0.981–1.685) | |
| Recessive | 0.402 | 1.307 (0.599–2.446) | 0.934 | 0.968 (0.454–2.066) | ||
| Additive | 0.020 | 1.256 (1.036–1.521) | 0.121 | 1.202 (0.853–1.518) | ||
| rs12641823 | Dominant | 0.906 | 1.014 (0.810–1.268) | 0.617 | 1.071 (0.819–1.399) | |
| Recessive | 0.260 | 0.864 (0.669–1.115) | 0.559 | 0.914 (0.675–1.236) | ||
| Additive | 0.565 | 0.959 (0.831–1.106) | 0.989 | 0.999 (0.841–1.186) | ||
| CAD | rs3749585 | Dominant | 0.355 | 1.093 (0.905–1.319) | 0.721 | 0.963 (0.781–1.186) |
| Recessive | 0.090 | 0.834 (0.676–1.029) | 0.119 | 0.833 (0.662–1.048) | ||
| Additive | 0.688 | 0.976 (0.867–1.099) | 0.250 | 0.925 (0.809–1.057) | ||
| rs4695253 | Dominant | 0.336 | 0.907 (0.743–1.107) | 0.116 | 0.839 (0.675–1.044) | |
| Recessive | 0.702 | 0.888 (0.485–1.627) | 0.293 | 0.707 (0.370–1.349) | ||
| Additive | 0.336 | 0.917 (0.768–1.094) | 0.090 | 0.847 (0.699–1.026) | ||
| rs12641823 | Dominant | 0.756 | 0.970 (0.803–1.173) | 0.884 | 1.016 (0.824–1.252) | |
| Recessive | 0.986 | 1.002 (0.812–1.237) | 0.823 | 1.027 (0.814–1.295) | ||
| Additive | 0.850 | 0.988 (0.875–1.116) | 0.824 | 1.015 (0.88–1.161) | ||
SNP, single-nucleotide polymorphisms; 3'UTR, 3 untranslated region; OR, odds ratio; CI, confidential interval; AF, atrial fibrillation; HF, heart failure; CAD, coronay artery disease; Padj, P-value for association after adjusting for covariates by multiple logistic regression analysis using SPSS version 22.0; Pobs, P-value for association before adjusting for covariates by 2 × 2 contingence tables using PLINK version 1.07. The bold values mean P < 0.05.