Table 5.
Analysis of genotypic association of SNPs in 3' UTR of CORIN with lipid levels under different genetic inheritance models.
| Lipid | SNP | Model | Without adjustment | With adjustment | ||
|---|---|---|---|---|---|---|
| Pobs | β (95% CI) | Padj | β (95% CI) | |||
| TG | rs3749585 | Dominant | 0.117 | (−8.849) (−19.921 to 2.224) | 0.142 | (−8.266) (−19.293 to 2.762) |
| Recessive | 0.206 | (−7.706) (−19.664 to 4.253) | 0.166 | (−8.406) (−20.307 to 3.496) | ||
| Additive | 0.080 | (−6.317) (−13.395 to 0.760) | 0.079 | (−6.318) (−13.361 to 0.724) | ||
| rs4695253 | Dominant | 0.426 | 4.079 (−5.960 to 14.118) | 0.374 | 4.529 (−5.467 to 14.525) | |
| Recessive | 0.305 | 15.683 (−14.305 to 45.671) | 0.263 | 17.037 (−12.812 to 46.885) | ||
| Additive | 0.314 | 4.552 (−4.313 to 13.417) | 0.264 | 5.027 (−3.804 to 13.857) | ||
| rs12641823 | Dominant | 0.716 | 1.769 (−7.754 to 11.291) | 0.228 | 1.101 (−8.378 to 10.580) | |
| Recessive | 0.935 | 0.475 (−10.947 to 11.897) | 0.958 | (−0.303) (−11.666 to 11.060) | ||
| Additive | 0.776 | 0.910 (−5.359 to 7.178) | 0.904 | 0.385 (−5.852 to 6.622) | ||
| HDL | rs3749585 | Dominant | 0.395 | (−0.515) (−1.702 to 0.671) | 0.273 | (−0.655) (−1.825 to 0.515) |
| Recessive | 0.171 | (−0.896) (−2.178 to 0.387) | 0.173 | (−0.879) (−2.144 to 0.385) | ||
| Additive | 0.176 | (−0.524) (−1.283 to 0.235) | 0.132 | (−0.575) (−1.323 to 0.173) | ||
| rs4695253 | Dominant | 0.156 | 0.910 (−0.349 to 2.169) | 0.255 | 0.636 (−0.523 to 1.973) | |
| Recessive | 0.004 | 5.500 (1.745 to 9.255) | 0.008 | 5.053 (1.331–8.775) | ||
| Additive | 0.036 | 1.190 (0.079 to 2.301) | 0.073 | 1.008 (−0.094 to 2.110) | ||
| rs12641823 | Dominant | 0.703 | (−0.228) (−1.401 to 0.945) | 0.504 | (−0.396) (−1.557 to 0.766) | |
| Recessive | 0.637 | 0.339 (−1.069 to 1.747) | 0.576 | 0.397 (−0.996 to 1.790) | ||
| Additive | 0.993 | 0.003 (−0.769 to 0.776) | 0.894 | (−0.052) (−0.817 to 0.713) | ||
| TC | rs3749585 | Dominant | 0.467 | (−1.944) (−7.187 to 3.299) | 0.356 | (−2.439) (−7.615 to 2.737) |
| Recessive | 0.414 | (−2.364) (−8.033 to 3.305) | 0.403 | (−2.386) (−7.980 to 3.208) | ||
| Additive | 0.343 | (−1.623) (−4.976 to 1.730) | 0.278 | (−1.831) (−5.138 to 1.477) | ||
| rs4695253 | Dominant | 0.227 | 3.110 (−1.937 to 8.156) | 0.344 | 2.411 (−2.580 to 7.402) | |
| Recessive | 0.022 | 17.597 (2.533 to 32.660) | 0.036 | 15.944 (1.050–30.837) | ||
| Additive | 0.081 | 3.963 (−0.492 to 8.418) | 0.145 | 3.277 (−1.131 to 7.686) | ||
| rs12641823 | Dominant | 0.730 | 0.829 (−3.886 to 5.545) | 0.988 | 0.034 (−4.623 to 4.692) | |
| Recessive | 0.909 | (−0.331) (−5.991 to 5.328) | 0.946 | (−0.193) (−5.778 to 5.393) | ||
| Additive | 0.870 | 0.260 (−2.845 to 3.365) | 0.978 | (−0.043) (−3.108 to 3.022) | ||
| LDL | rs3749585 | Dominant | 0.745 | (−18.221) (−128.233 to 91.790) | 0.710 | (−20.833) (−130.874 to 82.209) |
| Recessive | 0.736 | (−20.462) (−139.349 to 98.424) | 0.776 | (−17.250) (−136.085 to 101.585) | ||
| Additive | 0.684 | (−14.615) (−84.959 to 55.730) | 0.685 | (−14.541) (−84.845 to 55.763) | ||
| rs4695253 | Dominant | 0.725 | (−17.549) (−115.543 to 80.444) | 0.696 | (−19.569) (−117.665 to 78.527) | |
| Recessive | 0.684 | (−60.645) (−353.296 to 232.005) | 0.656 | (−66.509) (−359.358 to 226.340) | ||
| Additive | 0.667 | (−18.991) (−105.531 to 67.550) | 0.633 | (−21.100) (−107.767 to 65.567) | ||
| rs12641823 | Dominant | 0.763 | (−14.567) (−109.422 to 80.288) | 0.816 | (−11.253) (−106.165 to 83.659) | |
| Recessive | 0.882 | (−8.624) (−122.361 to 105.113) | 0.920 | (−5.805) (−119.537 to 107.926) | ||
| Additive | 0.780 | (−8.914) (−71.363 to 53.535) | 0.835 | (−6.624) (−69.081 to 55.834) | ||
SNP, single-nucleotide polymorphisms; 3'UTR, 3 untranslated region; CI, confidential interval; TG, triglyceride; HDL, high density lipoprotein; TC, total cholesterol; LDL, low density lipoprotein; Padj, P-value for association after adjusting for covariates by multiple logistic regression analysis using SPSS version 22.0; Pobs, P-value for association before adjusting for covariates by linear logistic regression using PLINK version 1.07. The bold values mean P < 0.05.