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. 2021 Aug 16;21:203. doi: 10.1186/s12871-021-01423-5

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© The Author(s) 2021

Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated in a credit line to the data.

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Fig. 4 — ROCK1 is the downstream target gene of miR-214. A Target genes of miR-214 predicted by Starbase, TargetScan, miRWalk and miRDB databases. B The mRNA expression of predicted target genes in brain tissues of rats injected with miR-214 inhibitor or NC inhibitor detected by RT-qPCR. C ROCK1 protein expression in brain tissues of rats injected with miR-214 inhibitor or NC inhibitor determined by immunohistochemistry. D Sequences for binding sites between miR-214 and ROCK1. E Luciferase activity of ROCK1-WT and ROCK1-MT after treatment of miR-214 mimic examined by dual-luciferase reporter assay. For panel C, comparison was made using unpaired t test. * p < 0.05 compared with rats injected with NC inhibitor. For panel B and E, comparisons were made using one-way or two-way ANOVA, respectively. * p < 0.05 compared with rats injected with NC inhibitor; # p < 0.05 compared with rats injected with NC mimic