. 2021 Aug 16;21:327. doi: 10.1186/s12893-021-01323-y

Table 2.

Univariable and multivariable analysis of factors associated with OS of CRLM after first recurrence

	Univariable analysis			Multivariable analysis
	HR	95%	P value	HR	95%	P value
Age
> 70	Ref	0.869–2.461	0.153	Ref	0.777–2.366	0.284
≤ 70	1.462	0.869–2.461	0.153	1.356	0.777–2.366	0.284
Sex
Male	Ref	0.670–1.322	0.726	Ref	0.586–1.201	0.336
Female	0.941	0.670–1.322	0.726	0.838	0.586–1.201	0.336
Primary T stage
1–2	Ref	0.515–1.355	0.465	Ref	0.502–1.424	0.529
3–4	0.835	0.515–1.355	0.465	0.846	0.502–1.424	0.529
Primary N stage
N0	Ref	1.265–2.734	0.002	Ref	1.227–2.809	0.003
N1-2	1.860	1.265–2.734	0.002	1.857	1.227–2.809	0.003
Location tumor
Colon	Ref	0.600–1.159	0.279	Ref	0.517–1.187	0.249
Rectum	0.834	0.600–1.159	0.279	0.783	0.517–1.187	0.249
Primary tumor location
Left	Ref	0.834–1.734	0.322	Ref	0.770–1.973	0.383
Right	1.203	0.834–1.734	0.322	1.233	0.770–1.973	0.383
Timing of liver metastasis
> 12 month	Ref	0.588–1.435	0.708	Ref	0.613–1.644	0.970
≤ 12 month	0.981	0.588–1.435	0.708	1.010	0.613–1.644	0.970
CEA
> 50	Ref	0.451–1.443	0.455	Ref	0.408–1.515	0.472
≤ 50	0.798	0.451–1.443	0.455	0.786	0.408–1.515	0.472
CA199
> 100	Ref	0.675–1.974	0.600	Ref	0.690–2.333	0.444
≤ 100	1.154	0.675–1.974	0.600	1.269	0.690–2.333	0.444
Tumor size
≤ 3 cm	Ref	1.074–2.222	0.035	Ref	1.037–2.810	0.036
> 3 cm	1.441	1.074–2.222	0.035	1.707	1.037–2.810	0.036
Tumor no
≤ 1	Ref	1.006–1.942	0.046	Ref	0.424–1.268	0.733
> 1	1.398	1.006–1.942	0.046	0.733	0.424–1.268	0.733
RAS status
Wild	Ref	1.183–2.281	0.003	Ref	1.080–2.234	0.017
Mutation	1.634	1.183–2.281	0.003	1.553	1.080–2.234	0.017
Distribution
Unilobar	Ref	1.094–2.205	0.014	Ref	0.806–2.380	0.238
Bilobar	1.553	1.094–2.205	0.014	1.385	0.806–2.380	0.238
Early recurrence
No	Ref	1.387–2.725	0.000	Ref	1.148–2.523	0.008
Yes	1.944	1.387–2.725	0.000	1.702	1.148–2.523	0.008
Local treatment
No	Ref	0.222–0.443	0.000	Ref	0.218–0.467	0.000
Yes	0.313	0.222–0.443	0.000	0.322	0.218–0.467	0.000