Table 2.
Gene ontology and pathway enrichment analysis of differentially expressed genes in mechanically stressed cartilage
| Term | Entry | Overlap | Adj P-valuea | Odds ratio | Genes |
|---|---|---|---|---|---|
| Cellular senescence | hsa04218 | 8/160 | 1.15 × 10−2 | 6.41 | GADD45A, MYC, SERPINE1, AKT3, EIF4EBP1, SLC25A5, ETS1, FOXO1 |
| Focal adhesion | hsa04510 | 8/199 | 1.33 × 10−2 | 5.15 | SHC4, CAV1, ITGA10, AKT3, LAMA3, TNC, COL9A3, TLN2 |
| Insulin-like growth factor II binding | GO:0031995 | 3/7 | 1.83 × 10−2 | 54.95 | IGFBP5, IGFBP4, IGFBP6 |
| Focal adhesion | GO:0005925 | 11/356 | 2.54 × 10−2 | 3.96 | ENAH, EHD3, GSN, CAV1, TNC, CD9, TLN2, RPL10A, DCAF6, RHOB, ENG |
| Insulin-like growth factor I binding | GO:0031994 | 3/13 | 2.89 × 10−2 | 29.59 | IGFBP5, IGFBP4, IGFBP6 |
aEnrichr uses a modified Fisher’s exact test to compute enrichment and this is reported as the adjusted P-value [29]. Legend: Adj P-value, adjusted P-value