Fig. 5.

Alteration of gut microbiome in PS cDKO mice. The α-diversity indexes of Chao1 (A) and Shannon (B) of gut microbiota between PS cDKO and control mice. *, P < 0.05, **, P < 0.01. PCoA (C and D) and PLS-DA (E and F) of the gut microbiome composition of WT and PS cDKO mice on OTU level at age of 2 and 6 months. G and H: Relative abundance of the gut microbiome in WT and PS cDKO mice at age of 2 and 6 months, coloured at the phylum (G) and genus (H) level. I: The effect of the gut microbiota modifications in PS cDKO mice at age of 6 months compared with age-matched WT mice on predicted functional metabolic pathways acquired from PICRUSt analysis, N = 6