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. 2021 Aug 16;28:20. doi: 10.1186/s40709-021-00151-8

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© The Author(s) 2021

Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated in a credit line to the data.

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Fig. 7 — miR-193a-5p targeted COL1A1. A The downstream pathways modulated by miR-193a-5p was analyzed via mirPath v.3 (http://snf-515788.vm.okeanos.grnet.gr/index.php?r=mirpath). B TargetScan database (http://www.targetscan.org/vert_72/) was used for predicting the binding sites between miR-193a-5p and COL1A1. C RT-PCR was performed to test COL1A1 expression in CC tissues. D The diagnostic significance of COL1A1 in CC was analyzed via KM plotter (http://kmplot.com/analysis/). E The expression of COL1A1 in normal cervical tissues and cervical cancer tissues was analyzed in The Human Protein Alas (https://www.proteinatlas.org/). F luciferase reporter gene experiment was conducted to confirm the targeting relationship between miR-193a-5p and COL1A1. G, H Western blot was used for the detection of COL1A1 in CC cells with gain and loss of miR-193a-5p (G) and FBXL19-AS1 (H) expression. ns p > 0.05, **p < 0.01, ***p < 0.001 (n = 3)