Table 1.
Participant demographics
| Criteria | Number (%) | |
|---|---|---|
| Gender | Male | 107 (37.5) |
| Female | 178 (62.5) | |
| Ethnicity | White/Caucasian (non-Jewish) | 249 (87.4) |
| White/Caucasian (Jewish) | 19 (6.6) | |
| Middle Eastern (non-Jewish) | 4 (1.4) | |
| Middle Eastern (Jewish) | 1 (0.4) | |
| Asian | 2 (0.7) | |
| Hispanic | 2 (0.7) | |
| Other/Unknown | 8 (2.8) | |
| Mean (Range) | ||
| Age | Overall | 55.5 (27-79y) |
| Male | 56.4 (30-78y) | |
| Female | 54.9 (27-79y) | |
| PC Family History | Number of participants (Kindreds) |
Youngest PC diagnosis in kindred (Years) Mean (range) |
| FPC | 203 (134) | 58 (21–84) |
| BRCA2 GPV + ≥1FDR/SDR PC | 55b (38) | 59 (39–84) |
| PALB2 GPV + ≥1FDR/SDR PC | 12c (7) | 50 (25–76) |
| CDKN2A GPV + ≥1FDR/SDR PC | 9 (4) | 55 (43–71) |
| Lynch syndrome+ ≥ 1FDR/SDR PC | 1 (1) | 80 |
| Hereditary Pancreatitis | 2 (2) | 54 |
| Peutz-Jeghers syndromea | 3 (3) | N/A |
aclinical diagnosis or STK11 GPV; b n = 2 at 50% risk; c n = 1 at 50% risk; GPV germline pathogenic variant; FDR first-degree relative; SDR second-degree relative