. 2021 Jul 16;12(8):1275–1282. doi: 10.1021/acsmedchemlett.1c00264

Table 3. Physicochemical Properties and Cell-Based Activity of Key Compounds.

compound	pH 7 solubility^a (μM)	MDCKII Papp (×10^–6 cm/s)^b	pVASP (ser 239) cell assay (μM)
1	120	2	>164
2	154	15	12
21	60	19	8.8
22	74	14	28
23	85	16	15
26	154	11	141
27	128	4	140

See the Supporting Information for the assay protocol.

Permeability measured according to a published procedure.³⁶