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TMX-3063 labels CDK2 in cells. (A) Chemical structure of TMX-3052 and its CDK2/cyclin A inhibitory activity. (B) OVCAR8 cells were pretreated with either DMSO or TMX-3063 (1 μM) for 4 h followed by cell lysis, and the cell lysates were then incubated with TMX-3052 (1 μM) for 16 h. The protein was denatured with 4 mM urea + 1% SDS to eliminate the reversible binding.
