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. 2021 Aug 2;12(8):1342–1349. doi: 10.1021/acsmedchemlett.1c00363

Table 2. hM4 Potency, M2 Selectivity, CYP Inhibition, and P-gp Efflux for Compounds 11a and 11b.

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a

Calcium mobilization assays with (a) hM4. IC50 values for hM4 represent means from at least three (n = 3) independent experiments performed in triplicate.

b

hM2/Gqi5-CHO cells performed in the presence of an EC80 fixed concentration of acetylcholine. IC50 values for hM2 represent one independent experiment performed in triplicate.

c

Cytochrome P450 cocktail inhibition assay in human liver microsomes (see SI for further details).

d

BBB penetration potential using MDR1-MDCK cell monolayers; ER is defined as Papp(B-to-A)/Papp(A-to-B) (see SI for further details).

e

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