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. 2021 Aug 2;12(8):1342–1349. doi: 10.1021/acsmedchemlett.1c00363

Table 4. Predicted Human PK Parameters for VU6028418 (8i).

pred. human CLpa pred. human Vssb pred. human t1/2
3.9 mL/min/kg 11 L/kg 31 h
a

IVIVE approach with empirical correction factors using mean rat and dog in vivo data.

b

Scaling of unbound Vss using mean rat and dog in vivo data.

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