Table 3. In Vitro Antiplasmodium and solubility of AST Analogues in SAR 2 (ND, Not Determined).

^aMean from n ≥ 2 independent experiments with sensitive (NF54) and multi-drug-resistant (K1) strains of Pf.

^bChloroquine (NF54 IC₅₀ = 0.004 μM; K1 IC₅₀ = 0.14 μM) was used as a reference drug for activity.

^cResistance index = [PfK1 IC₅₀/PfNF54 IC₅₀].

^dSolubility, determined using turbidimetric method at pH 7.4. Hydrocortisone (>200 μM) and reserpine (<10 μM) were used as control drugs.