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. 2021 Jul 19;12(8):1230–1237. doi: 10.1021/acsmedchemlett.1c00305

Table 1. Compound Profiles, Rat PK, and Rat AITC Target Engagement for TRPA1 Antagonists.

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a

Data for the corresponding prodrug.13

b

PPB was determined in rat with 4 h compound incubation time (compared to standard 24 h due to compound instability in rat plasma).