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. 2021 Jul 14;12(8):1283–1287. doi: 10.1021/acsmedchemlett.1c00273

Table 3. Cell Activity and Selected Parameters.

compd cell IC50a (nM) PAMPA (nm/s) HPLC LogD (pH = 7.4) kinetic solubility (μg/mL)
2 196 258 2.5 6.3
3 225 257 2.8 7.5
11 102 280 2.7 0.38
12 92 274 2.9 1.3
a

Human 4-4 cell data: compounds were tested at minimum in triplicate.