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. 2021 Aug 2;15:695670. doi: 10.3389/fnins.2021.695670

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Copyright © 2021 Dou, Li, Ma, Xu, Fan, Tian, Chen, Li, Gong, Lyu, Fang, Liu, Xu, Wang, Chen, Guo, Guo and Lin.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Role of neuroimmune crosstalk at the acupoint in mediating the anti-inflammatory and analgesic effects of acupuncture on inflammatory pain. The names of immune factors are presented in red and green, respectively. The factors in red are up-regulated by acupuncture, while those in green are down-regulated by acupuncture. NF-κB, nuclear factor kappa-B; TRPV1/2/4, transient receptor potential ion channel vanilloid 1/2/4; MCP-1, monocyte chemoattractant protein-1; IL-16, interleukin- 6.