TABLE 1.
The clinicopathological characteristics and stromal score of PTC patients in the training and validation cohorts
| Variables |
Total (n = 381) |
Training cohort (n = 269) |
Validation cohort (n = 112) |
p |
|---|---|---|---|---|
| Age (year) | 0.961 | |||
| ≤57 | 283 (74.28) | 200 (74.35) | 83 (74.11) | |
| >57 | 98 (25.72) | 69 (25.65) | 29 (25.89) | |
| Sex | 0.206 | |||
| Female | 279 (73.23) | 192 (71.38) | 87 (77.68) | |
| Male | 102 (26.77) | 77 (28.62) | 25 (22.32) | |
| Race | 0.609 | |||
| White | 311 (81.63) | 223 (82.90) | 88 (78.57) | |
| Black | 23 (6.04) | 15 (5.58) | 8 (7.14) | |
| Other | 47 (12.33) | 31 (11.52) | 16 (14.29) | |
| Radiation therapy | 0.125 | |||
| No | 145 (38.06) | 109 (40.52) | 36 (32.14) | |
| Yes | 236 (61.94) | 160 (59.48) | 76 (67.86) | |
| Histological type | 0.876 | |||
| CPTC | 289 (75.85) | 201 (74.72) | 88 (78.57) | |
| FVPTC | 54 (14.17) | 39 (14.50) | 15 (13.39) | |
| TCPTC | 32 (8.41) | 24 (8.92) | 8 (7.14) | |
| Other | 6 (1.57) | 5 (1.86) | 1 (0.90) | |
| AJCC TNM stage | 0.450 | |||
| Stage I | 217 (56.96) | 151 (56.13) | 66 (58.93) | |
| Stage II | 33 (8.66) | 24 (8.92) | 9 (8.04) | |
| Stage III | 91 (23.88) | 69 (25.65) | 22 (19.64) | |
| Stage IV | 40 (10.50) | 25 (9.29) | 15 (13.39) | |
| T status | 0.669 | |||
| T1 | 101 (26.51) | 72 (26.77) | 29 (25.89) | |
| T2 | 125 (32.81) | 89 (33.09) | 36 (32.14) | |
| T3 | 136 (35.70) | 97 (36.06) | 39 (34.82) | |
| T4 | 19 (4.98) | 11 (4.09) | 8 (7.14) | |
| N status | 0.847 | |||
| N0 | 173 (45.41) | 124 (46.10) | 49 (43.75) | |
| N1 | 178 (46.72) | 125 (46.47) | 53 (47.32) | |
| NX | 30 (7.87) | 20 (7.43) | 10 (8.93) | |
| M status | 0.266 | |||
| M0 | 253 (66.40) | 185 (68.77) | 68 (60.71) | |
| M1 | 7 (1.84) | 4 (1.49) | 3 (2.68) | |
| MX | 121 (31.76) | 80 (29.74) | 41 (36.61) | |
| Stromal score | 0.974 | |||
| ≤ −667.0 | 139 (36.48) | 98 (36.43) | 41 (36.61) | |
| >−667.0 | 242 (63.52) | 171 (63.57) | 71 (63.39) |
Abbreviations: AJCC TNM, American Joint Committee on Cancer Tumor Node Metastasis; CPTC, classical PTC; FVPTC, follicular variant PTC; M, Metastasis; MX, metastasis cannot be measured; N, Node; NX, cancer in nearby lymph nodes cannot be measured; PTC, papillary thyroid carcinoma; T, Tumor; TCPTC, tall cell PTC.