FIGURE 3.

Allometric body shape index tertiles in relation to cancer risk by sex. †—cancers with less than 20 cases in women pre‐menopausal at baseline, for which models were not adjusted for menopausal status; ABSI, a body shape index; BMI, body mass index, categorized according to the World Health Organization as normal weight (≥18.5 to <25 kg/m²), overweight (≥25 to <30 kg/m²) or obese (≥30 to <45 kg/m²); CI, confidence interval; HI, hip index; HR, hazard ratio; SCC, squamous cell carcinoma; T1‐T3, sex‐specific tertiles for ABSI, HI, and WHI; WHI, waist‐to‐hip index. HRs (95% CI) were obtained from delayed entry Cox proportional hazards models stratified by age at baseline and region of the assessment center. Model A—included BMI and WHI with adjustment variables. Model B—included BMI, ABSI, and HI with adjustment variables. Men—models were adjusted for height, weight change during the year preceding baseline, Townsend deprivation index, smoking status, alcohol consumption, physical activity, consumption of fresh fruit and vegetables, processed meat and red meat, family history of cancer, and, for skin SCC and melanoma, sun‐exposure‐related factors. Women—models included adjustment variables as for men, with the addition of menopausal status (except for cancers marked with †), use of hormone replacement therapy, ever use of oral contraceptives, and age at last live birth (with “no live births” as one of the categories). Grey background rectangles—highlight associations with nominal statistical significance (p < 0.05) for the corresponding continuous variable, representing a test for linear trend. Cancer types and subtypes are defined in Supplementary Methods according to the 10th edition of the International Statistical Classification of Diseases (ICD10). This figure includes cancers showing statistically significant associations with allometric body shape indices used as continuous variables (highlighted in grey rectangles), or isolated associations with allometric body shape indices used as categorical variables. Numerical values for all HR (95% CI) estimates, derived from models for cancers with at least 10 cases per BMI category and body shape index tertile, are shown in Table S3