TABLE 2.
Comparison of median DFS and OS time in entire series (Kaplan–Meier method)
| Variables | n | DFS | p | OS | p |
|---|---|---|---|---|---|
| HBsAg | 0.935 | 0.932 | |||
| Positive | 272 | 10.0 ± 0.9 | 38.5 ± 13.2 | ||
| Negative | 54 | 14.1 ± 4.8 | 39.0 ± 16.2 | ||
| Background liver | 0.609 | 0.674 | |||
| Normal | 116 | 11.0 ± 1.4 | 39 ± 13.3 | ||
| Cirrhosis | 210 | 10.0 ± 1.6 | 39.0 ± 14.8 | ||
| Histological grade | 0.028 | 0.648 | |||
| Well differentiated | 192 | 10.8 ± 2.2 | 39.0 ± 13.7 | ||
| Poorly differentiated | 134 | 10.0 ± 1.3 | 38.5 ± 14.4 | ||
| Microvascular invasion | <0.001 | 0.002 | |||
| Present | 90 | 13.8 ± 1.8 | 46.0 ± 14.1 | ||
| Absent | 236 | 5.7 ± 0.9 | 27.0 ± 13.5 | ||
| AFP at recurrence, ng/ml | 0.204 | 0.123 | |||
| > 20 | 108 | 11.0 ± 3.4 | 43.5 ± 14.6 | ||
| ≤ 20 | 218 | 10.0 ± 1.2 | 36.5 ± 9.4 | ||
| Child‐Pugh score at recurrence | 0.148 | 0.195 | |||
| 5 | 146 | 11.0 ± 1.5 | 34.5 ± 11.5 | ||
| 6 | 180 | 10.0 ± 1.6 | 44.0 ± 13.5 | ||
| Tumor multiplicity at recurrence | 0.094 | 0.686 | |||
| Solitary | 267 | 11 ± 1.5 | 39 ± 17.9 | ||
| Multiple | 59 | 7 ± 2.3 | 39 ± 14.3 | ||
| Time to recurrence | <0.001 | <0.001 | |||
| < 1 year | 144 | 7.0 ± 0.9 | 33 ± 8.3 | ||
| ≥ 1 year | 182 | 18.0 ± 2.7 | 50.5 ± 15.0 | ||
| VETC | 0.011 | 0.002 | |||
| Positive | 119 | 6.9 ± 1.4 | 27.0 ± 10.1 | ||
| Negative | 207 | 12.0 ± 1.8 | 46.0 ± 13.5 | ||
| Treatment allocation | 0.114 | 0.259 | |||
| RHR | 138 | 11.8 ± 3.3 | 42.0 ± 12.6 | ||
| RFA | 188 | 10.0 ± 1.1 | 37.5 ± 10.4 |
Abbreviations: AFP, α‐fetoprotein; DFS, disease‐free survival; OS, overall survival; RFA, radiofrequency ablation; RHR, repeat hepatic resection; VETC, vessels encapsulating tumor clusters.