TABLE 4.

Multivariate analysis of the prognostic factors for extrahepatic cholangiocarcinoma (ECC) and intrahepatic cholangiocarcinoma (ICC)

	Overall survival			Recurrence‐free survival
	Adjusted HR	95% CI	p	Adjusted HR	95% CI	p
ECC (n = 96) SNCG
Positive	2.6	1.1–6.2	0.03	1.9	1.0–3.7	0.04
Negative	1.0			1.0
ICC (n = 51) SNCG
Positive	3.6	1.2–11.2	0.03	3.6	1.2–10.5	0.02
Negative	1.0			1.0

For ECC, we adjusted for CA19‐9, surgical procedure, tumor differentiation, depth of invasion, invasion to other organs, perineural invasion, lymphatic invasion, vascular invasion, lymph node metastasis, and curability.

For ICC, we adjusted for age, CA19‐9 (only for overall survival), tumor differentiation, lymphatic invasion, vascular invasion (only for overall survival), lymph node metastasis, and curability.

Abbreviations: CA19‐9, carbohydrate antigen 19‐9; CI, confidential interval; HR, hazard ratio; SNCG, gamma‐synuclein.