Table 3.

Variants of concern (VOC).

Additional mutations and lineage	First detected	Substitutions on spike protein	Impact on immunity evidence
B.1.1.7 (20I/501Y.V1)	United Kingdom (Sept 2020)	Δ69/70, Δ144, (E484K*), (S494P*), N501Y, A570D, D614G, P681H, T716I, S982A, D1118H (K1191N*)	Unclear [2]
B.1.1.7 + E484K	United Kingdom (Dec 2020)	E484K, N501Y, D614G	Neutralisation (v) [2,5]
B.1.351 (20H/501.V2)	South Africa (Sep 2020)	D80A, D215G, Δ241/242/243, K417N, E484K, N501Y, D614G, A701V	Escape (v) [7,8]
B.1.427 (20C/S:452R)	U.S.A (California)	L452R, D614G	Neutralisation (v)
B.1.429 (20C/S:452R)	U.S.A (California)	S13I, W152C, L452R, D614G	Neutralisation (v)
P.1 (20J/501Y.V3)	Japan/Brazil	L18F, T20N, P26S, D138Y, R190S, K417T, E484K, N501Y, D614G, H655Y, T1027I	Neutralisation (v) [11]

* = Aminoacid substitution on the variants.