Table 4.
Variants of interest (VOI) [2].
| Additional mutations and lineage | First detected | Substitutions on spike protein | Impact on immunity evidence |
|---|---|---|---|
| B.1.525 | Nigeria (Dec 2020) | E484K, D614G, Q677H | Neutralisation |
| B.1.427/B.1.429 | United States (Sep 2020) | L452R, D614G | Neutralisation |
| P.3 | The Philippines (Jan 2021) | E484K, N501Y, D614G | Neutralisation |
| B.1.616 | France (Feb 2021) | V483A, D614G, H655Y, G669S | |
| B.1.617 (20A) | India (Feb 2020) | L452R, E484Q, D614G | |
| B.1.617.1 (20A/S:154K) | India (Dec 2020) | (T95I), G142D, E154K, L452R, E484Q, D614G, P681R, Q1071H | Neutralisation |
| B.1.617.2 (20A/S:478K) | India (Dec 2020) | T19R, (G142D), Δ156, Δ157, R158G, L452R, T478K, D614G, P681R, D950N | Neutralisation |
| B.1.617.3 (20A) | India (Oct 2020)/(Feb 2021) | T19R, G142D, L452R, E484Q, D614G, P681R, D950N | Neutralisation |
| B.1.620 | Place not clear (Feb 2021) | S477N, E484K, D614G | Neutralisation |
| B.1.621 | Colombia (Jan 2020) | R346K, E484K, N501Y, D614G | Neutralisation |