Table 1.
Studies included in the meta-analysis.
| Author | Year | N | Age (years) | Males (N) | Females (N) | Rating scale | MÅDRS (C) severity | Disease duration (years) | Criteria | Time to response | Units males (N) | Units females (N) | % MÅDRS (C) reduction |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Wollmer et al. | 2012 | 15 | 52.2 | 3 | 12 | HAMD17 | 21.4 | 11.97 | DSM IV | 6 weeks | 39 | 29 | 48.3 |
| Finzi et al. | 2014 | 41 | 47.9 | 9 | 32 | MADRS | 31.6 | – | DSM IV | 6 weeks | 40 | 29 | 46.5 |
| Magid et al., I | 2014 | 11 | 48.5 | 0 | 11 | HAMD21 | 22 | 16.09 | DSM IV | 6 weeks | 39 | 29 | 58.7 |
| Magid et al., II | 2014 | 19 | 50 | 2 | 17 | HAMD21 | 20.16 | 18.05 | DSM IV | 6 weeks | 39 | 29 | 43.2 |
| Zamanian et al. | 2017 | 14 | 35.14 | 7 | 7 | BDI | 30.86 | 3.71 | DSM 5 | 6 weeks | – | – | 43.4 |
| Brin et al. (30 IU) | 2020 | 65 | 43.6 | 0 | 65 | MÅDRS | 32 | 12.3 | DSM IV-TR | 6 weeks | 0 | 30 | 36.2 |
| Brin et al. (50 IU) | 2020 | 65 | 44.4 | 0 | 65 | MÅDRS | 32 | 12.2 | DSM IV-TR | 6 weeks | 0 | 50 | 35.9 |
| Mean values (%) | 230 | 45.97 | 21 (0.091%) | 209 (90.8%) | 27.14 | 12.39 | 26.16 | 32.67 | 44.6 |
HAMD17: Hamilton Depression Rating Scale 17 items; HAMD21: Hamilton Depression Rating Scale 21 items; BDI: Beck Depression Rating Scale; MÅDRS: Montgomery-Åsberg Depression Rating Scale; MÅDRS (C): Montgomery-Åsberg Depression Rating Scale converted scores.