Table 3.
Multivariable MR associations of cannabis use with cardiovascular diseases adjusted for tobacco use and BMI.
| Outcome | Method | OR (95% CI) | p-value |
|---|---|---|---|
| CAD | IVW adjusted for Tobacco | 1.06 (0.98–1.15) | 0.16 |
| IVW adjusted for BMI | 0.99 (0.94–1.05) | 0.77 | |
| MI | IVW adjusted for Tobacco | 1.02 (0.93–1.12) | 0.65 |
| IVW adjusted for BMI | 0.97 (0.92–1.03) | 0.36 | |
| AS | IVW adjusted for Tobacco | 1.00 (0.92–1.08) | 0.93 |
| IVW adjusted for BMI | 1.00 (0.94–1.06) | 0.90 | |
| AIS | IVW adjusted for Tobacco | 1.00 (0.92–1.10) | 0.92 |
| IVW adjusted for BMI | 0.99 (0.93–1.05) | 0.75 | |
| LAS | IVW adjusted for Tobacco | 1.01 (0.84–1.20) | 0.93 |
| IVW adjusted for BMI | 0.95 (0.85–1.06) | 0.36 | |
| CES | IVW adjusted for Tobacco | 0.92 (0.79–1.08) | 0.30 |
| IVW adjusted for BMI | 0.97 (0.88–1.07) | 0.55 | |
| SVS | IVW adjusted for Tobacco | 1.17 (1.02–1.35) | 0.03 |
| IVW adjusted for BMI | 1.07 (0.98–1.16) | 0.15 | |
| AF | IVW adjusted for Tobacco | 1.03 (0.97–1.10) | 0.32 |
| IVW adjusted for BMI | 1.06 (1.01–1.10) | 0.01 | |
| HF | IVW adjusted for Tobacco | 1.03 (0.96–1.10) | 0.45 |
| IVW adjusted for BMI | 0.99 (0.93–1.05) | 0.74 |
CAD, coronary artery disease; MI, myocardial infarction; AS, any stroke; AIS, any ischemic stroke; LAS, large artery stroke; CES, cardioembolic stroke; SVS, small vessel stroke; BMI, body mass index; p-value is for the genetic association.