Table 5.
Multivariable analysis of factors associated with major (grade 3-5) perioperative complications
| Variable | Univariate | Multivariable | ||
|---|---|---|---|---|
| HR (95% CI) | P | Adjusted HR (95% CI) | P | |
| Age group | ||||
| 65-74 | Reference | -- | Reference | -- |
| 75-84 | 2.76 (0.17-44.26) | 0.474 | 1.18 (0.43-3.27) | 0.747 |
| 85+ | 29.74 (2.65-334.09) | 0.006 | 4.66 (1.44-15.11) | 0.01 |
| BMI (kg/m2) - continuous | 0.98 (0.92-1.04) | 0.570 | 0.97 (0.91-1.04) | 0.420 |
| ECOG performance status | ||||
| 0 | Reference | -- | ||
| 1 | 1.42 (0.54-3.71) | 0.472 | ||
| 2 | 1.18 (0.15-9.19) | 0.871 | ||
| 3 | 7.9 (0.89-69.74) | 0.063 | ||
| 4 | 0 (0-0) | 1.000 | ||
| 5 | 0 (0-0) | 1.000 | ||
| 5 or more comorbidities | ||||
| No | Reference | Reference | -- | |
| Yes | 0.57 (0.61-4.04) | 0.349 | 1 (0.3-3.31) | 0.996 |
| Prior abdominal surgery | ||||
| No | Reference | -- | Reference | -- |
| Yes | 1.22 (0.53-2.82) | 0.635 | 1.39 (0.59-3.25) | 0.443 |
| Procedure | ||||
| Major | Reference | -- | Reference | -- |
| Minor | 3.45 (0.46-25.81) | 0.228 | 3.52 (0.46-26.9) | 0.225 |
| Frail | ||||
| No | Reference | -- | Reference | -- |
| Yes | 3.76 (1.35-10.44) | 0.011 | 3.25 (0.88-12.02) | 0.077 |
BMI, body mass index; ECOG, Eastern Cooperative Oncology Group
All variables were tested for multicollinearity. Clinically significant variables and variables with p<0.2 on univariate analysis were included in the multivariable analysis.