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. Author manuscript; available in PMC: 2021 Aug 16.
Published in final edited form as: Clin Cancer Res. 2020 May 6;26(14):3662–3670. doi: 10.1158/1078-0432.CCR-20-0073

Figure 1. Peritonoids are representative of the human tumors from which they are derived.

Figure 1.

Peritonoids (B, D, F) resemble the tumor cell morphology of the native tumor (A, C, E) and express intestinal epithelial markers (A-B H&E, C-D CDX2, E-F CK20). Scale bar 100μm. (G) Schema depicting our precision medicine screening platform to guide patient-specific treatment for patients with worst prognosis CRC. Peritonoids and peripheral blood mononuclear cells undergo next-generation whole exome sequencing (WES) to identify genetic alterations found in the tumor and germline of each patient. This is combined with medium-throughput drug panel testing to identify specific drug sensitivities for each patient. Results are presented to the medical oncology team to provide treatment change options should patients exhaust standard care chemotherapy.