Table 5.
Definition of M according to AJCC 8th edition [1].
| Category | Anatomic Site | LDH level |
|---|---|---|
| M0: No evidence of distant metastasis | N/A | N/A |
| M1 | Evidence of distant metastases | See below |
| M1a | Distant metastasis to skin, soft tissue including muscle, and/or nonregional lymph node | Not recorded or unspecified |
| M1a(0) | Not elevated | |
| M1a(1) | Elevated | |
| M1b | Distant metastasis to lung with or without M1a sites of disease | Not recorded or unspecified |
| M1b(0) | Not elevated | |
| M1b(1) | Elevated | |
| M1c | Distant metastasis to non-CNS visceral sites with or without M1a or M1b sites of disease | Not recorded or unspecified |
| M1c(0) | Not elevated | |
| M1c(1) | Elevated | |
| M1d | Distant metastasis to CNS with or without M1a, M1b, or M1c sites of disease | Not recorded or unspecified |
| M1d(0) | Normal | |
| M1d(1) | Elevated |