Table 1.

Timeline of episode of care.

Day 0	SARS-CoV-2 positive after rapid antigen test Regular domestic quarantine and daily monitoring of CRP plasma concentration and symptoms Difficulty sleeping
Day 2	Coughing irritation when trying to take a deep breath, coughing hurts
Day 3	Coughing persists
Day 4	Coughing for several hours, difficulty breathing without coughing irritation 2 hours of chills including severe sweating -> dehydration Performance slump
Day 5 Start of treatment 1st apheresis	The positive test result of the PCR from Day 0 is available Rapid CRP concentration increase on the two previous days Overall poor physical condition, fever Oxygen saturation of the blood was 89% Venous, typically dark, hypoxemic blood Dehydration with a picture of mild coagulopathy Fluid substitution with 250 ml NaCl before and during apheresis, nevertheless only low plasma flow (20 mL/min)
Day 6 2nd apheresis	Thorax X-ray Fluid substitution with 100 ml CaCl2 and 500 ml NaCl before apheresis; 250 ml NaCl during apheresis Overall poor physical condition, fever Patient received additional heparin starting halfway through apheresis
Day 7 3rd apheresis	300 ml NaCl during apheresis Patient is negative in Corona rapid test 6 mg dexamethasone as a pill for 7 days starting 2 h after apheresis
Day 8 4th apheresis End of treatment	Patient is more agile and subjectively fitter than on the previous days 500 ml NaCl during apheresis Deep sleep at night for the first time again with preserved hyperhidrosis
Day 9	Breathing improves to about 2/3 of normal
Day 10	Patient feels fit and can breathe deeply again 8 kg weight loss = 11% of body weight
Day 14	Follow-up thorax X-ray
Day 35	Transthoracic Echocardiography Resting Echocardiography
Day 49	Cardiac magnetic resonance imaging