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. 2021 Aug 2;11:699933. doi: 10.3389/fonc.2021.699933

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Copyright © 2021 Zhao, Jiang, Chen, Ma, Zhang, Zhou, Li and Jing

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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RORA inhibits the migration and invasion of GBM cells in vitro and blocks the epithelial-mesenchymal transition (EMT) in GBM. (A, B) qPCR (A) and western blotting (B) showing the validation of RORA overexpression. (C, D) Representative migration assay and transwell assay showing the migration rates and invasion rates of T98G cells and GSC4D with RORA overexpression, and the negative control. Scale bar = 100 μm. (E) Representative microphotographs showing the morphological changes in RORA-overexpressed T98G cells and GSC4D. Scale bar = 50 μm. (F, G) Representative immunofluorescence staining (F) and western blotting (G) showing the changes in E-cadherin, vimentin, and N-cadherin in T98G cells and GSC4D after RORA overexpression. Scale bar = 50 μm. EV, empty vector; OE, overexpression. All data are expressed as the mean ± SD (three independent experiments). ^***P < 0.001.