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. 2021 Aug 2;11:699933. doi: 10.3389/fonc.2021.699933

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Copyright © 2021 Zhao, Jiang, Chen, Ma, Zhang, Zhou, Li and Jing

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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CASC2 inhibits the migration, invasion, and EMT of GBM, and the inhibitory effects are reversed by RORA knockdown. (A, B) Representative migration assays and Transwell assays showing the migration rates and invasion rates, and representative microphotographs showing the morphological changes in CASC2-overexpressed GSC4D, reversed by RORA knockdown, and the negative control. The migration assay and Transwell assay: scale bar = 100 μm, microphotographs: scale bar = 50 μm. (C, D) Representative immunofluorescence staining (C) and western blotting (D) showing the changes in E-cadherin, vimentin, and N-cadherin in GSC4D with CASC2 overexpression, reversed by RORA knockdown. Scale bar = 50 μm. EV, empty vector; OE, overexpression; NC, negative control; KD, knockdown. All data are expressed as the mean ± SD (three independent experiments). ^*P < 0.05; ^**P < 0.01; ^***P < 0.001.