Table 1.
Association of mLOY with age, smoking, cancer risk and mortality.
| OR/HR | 95% CI | Association P-value | Heterogeneity P-value | |
|---|---|---|---|---|
| Age at DNA Collection | ||||
| Blood | 1.16 | (1.14–1.18) | <2.0×10−16 | 3.27×10−5 |
| Buccal | 1.10 | (1.08–1.12) | <2.0×10−16 | |
| Current Smoking | ||||
| Blood | 3.07 | (2.15–4.38) | 6.1×10−10 | 0.045 |
| Buccal | 1.81 | (1.25–2.64) | 1.9×10−3 | |
| Cancer Risk (All) | ||||
| Blood | 1.26 | (1.06–1.50) | 0.010 | 0.358 |
| Buccal | 1.48 | (1.10–1.99) | 0.010 | |
| Cancer Risk (DNA before Dx) | ||||
| Blood | 1.17 | (0.97–1.42) | 0.100 | 0.704 |
| Buccal | 1.07 | (0.70–1.62) | 0.760 | |
| Cancer Risk (DNA at or after Dx) | ||||
| Blood | 1.43 | (1.11–1.85) | 0.006 | 0.442 |
| Buccal | 1.69 | (1.20–2.37) | 0.003 | |
| All-cause Mortality* | ||||
| Blood | 0.87 | (0.73–1.03) | 0.100 | 0.526 |
| Buccal | 0.99 | (0.69–1.42) | 0.960 | |
| Cancer Mortality* | ||||
| Blood | 0.83 | (0.68–1.01) | 0.060 | 0.258 |
| Buccal | 1.07 | (0.72–1.58) | 0.750 |
*
Indicates Hazard Ratios (HR) are reported in place of Odds Ratios (OR). Age and smoking models are adjusted for smoking/age, contributing study and ancestry. Cancer risk models are adjusted for age, smoking, contributing study and ancestry. Mortality models are for individuals from prospective cohort studies with case DNA collected ≥1 year before cancer diagnosis and adjusted for age, smoking, cancer diagnosis, contributing study and body mass index. OR=Odds Ratio; HR=Hazard Ratio; 95% CI=95 Percent Confidence Interval; Dx=Cancer Diagnosis.