Figure 3.

Logistic regression results: relative odds of Clostridioides difficile infection (CDI) for each type of exposure as a function of the time between prior exposure and admission. Odds ratios are presented for the 3 different regression models based on CDI case definition: hospital-onset CDI (defined as secondary cases with length of stay >3 days; red), all secondary cases (green), and all CDI cases (blue). Regardless of CDI case definition, for each exposure there is a fairly consistent pattern where the risk of CDI decays with increasing time prior to admission. Exact values can be found in Supplementary Table 1. The slight downward trend for low-risk antibiotics in 1–31 days likely reflects the fact that the exposure risk window cannot be fully observed in this period (eg, a 14-day course of antibiotics beginning 7 days prior to admission). See Supplementary Figure 2 for similar trends for high- and low-risk antibiotics broken down by treatment duration ≤14 days or >14 days.