Figure 5.

Clinical laboratory kinetics between treatment groups A, Alanine aminotransferase (ALT). B, Creatinine. C, Troponin I. D, Creatine kinase). Red lines represent locally estimated scatterplot smoothing curves of control group values; gray-shaded bands, control group confidence interval; and red dashed horizontal lines, upper limits of normal. No confidence intervals are shown in C because values among controls were low (≤0.8 ng/mL) compared with extreme elevations in 2 nonhuman primate. (Serum urea nitrogen and aspartate aminotransferase plots are included in Supplement I, Supplementary Figure 8.) Abbreviations: ICU, intensive care unit; NE, norepinephrine.