FIGURE 4.

EL20 suppresses abnormal SR Ca²⁺ release events in induced pluripotent stem cell‐derived cardiomyocytes (iPSC‐CMs) derived from the catecholaminergic polymorphic ventricular tachycardia patient (CPVT) proband. A, Representative recordings of Ca²⁺ sparks in iPSC‐CMs from the CPVT proband in the absence and presence of EL20 (500‐nmol/L). B, Summary data showing that EL20 reduced the Ca²⁺ spark frequency (CaSpF) in stimulated iPSC‐CM compared to vehicle treatment. C, Dose‐dependence of Ca²⁺ spark frequency inhibition and IC₅₀ determination of EL20 (n = 9‐10 cells per group). Open circles represent individual cells. Data presented as mean ± SEM (*P < .05, **P < .01, and ***P < .001)