FIGURE 5.

Absence of detrimental effects on evoked systolic SR Ca²⁺ transients by EL20. A, Confocal line‐scan images (top) and transients (bottom) showing intracellular Ca²⁺ transients recorded in induced pluripotent stem cell‐derived cardiomyocytes (iPSC‐CMs) loaded with fluro‐4‐AM during 1‐Hz field stimulation pacing in the presence 500‐nmol/L EL20. B, Bar graph summarizing the Ca²⁺ transient amplitude in iPSCs from both the catecholaminergic polymorphic ventricular tachycardia patient proband and control individual. Open circles represent individual cells. Data presented as mean ± SEM (NS = not statistically significant.)