Table 3.
Genotype and allele frequencies of 13 single nucleotide polymorphism(s) demonstrating no significant association to type 2 diabetes mellitus treatment response.
| SNP | Genotype/ Allele | Control n (%) | Uncontrolled n (%) | OR (95% CI) | p Values |
|---|---|---|---|---|---|
| rs10783050 | TT | 52 (98.1) | 86 (98.9) | reference | |
| TC | 1 (1.9) | 0 (0.0) | 0.20 (0.01-5.06) | 0.331 | |
| T | 105 (99.1) | 172 (98.9) | reference | ||
| C | 1 (0.9) | 0 (0.0) | 0.20 (0.01-5.05) | 0.332 | |
| rs1143623 | CC | 48 (90.6) | 74 (85.1) | reference | |
| CG | 5 (9.4) | 11 (12.6) | 1.43 (0.47-4.36) | 0.533 | |
| C | 96 (90.6) | 159 (91.4) | reference | ||
| G | 10 (9.4) | 11 (6.3) | 0.66 (0.27-1.62) | 0.369 | |
| rs13266634 | CC | 50 (94.3) | 78 (89.7) | reference | |
| CT | 3 (5.7) | 8 (9.2) | 1.71 (0.43-6.75) | 0.444 | |
| 100 (94.3) | 164 (94.3) | reference | |||
| 6 (5.7) | 8 (4.6) | 0.81 (0.27-2.41) | 0.709 | ||
| rs13376631 | AA | 16 (30.2) | 22 (25.3) | reference | |
| GG | 11 (20.8) | 17 (19.5) | 1.12 (0.42-3.04) | 0.818 | |
| AG | 25 (13.3) | 37 (42.5) | 1.08 (0.47-2.44) | 0.860 | |
| 57 (53.8) | 81 (46.6) | reference | |||
| 47 (44.3) | 71 (40.8) | 1.06 (0.64-1.75) | 0.811 | ||
| rs1801282 | CC | 53 (100.0) | 86 (98.9) | monomorphic | monomorphic |
| C | 106 (100.0) | 172 (98.9) | – | ||
| rs249429 | TT | 28 (52.8) | 40 (46.0) | reference | |
| CC | 3 (5.7) | 6 (6.9) | 1.40 (0.32-6.07) | 0.650 | |
| CT | 22 (41.5) | 40 (46.0) | 1.27 (0.6258-2.5885) | 0.510 | |
| T | 78 (73.6) | 120 (69.0) | reference | ||
| C | 28 (26.4) | 52 (29.9) | 1.21 (0.70-2.07) | 0.500 | |
| rs2815752 | GG | 18 34.0) | 22 (25.3) | reference | |
| AA | 13 (24.5) | 20 (23.0) | 1.26 (0.49-3.21) | 0.630 | |
| GA | 22 (41.5) | 43 (49.4) | 1.60 (0.71-3.59) | 0.254 | |
| 58 (54.7) | 87 (50.0) | reference | |||
| 48 (45.2) | 83 (47.7) | 1.15 (0.71-3.59) | 0.567 | ||
| rs34834489 | GG | 46 (86.7) | 80 (92.0) | reference | |
| GA | 6 (11.3) | 6 (6.9) | 0.58 (0.18-1.89) | 0.361 | |
| 98 (92.5) | 166 (95.4) | reference | |||
| 6 (5.7) | 6 (3.4) | 0.59 (0.19-1.88) | 0.373 | ||
| rs391300 | CC | 9 (17.0) | 17 (19.5) | reference | |
| TT | 18 (34.0) | 24 (27.6) | 0.71 (0.26-1.94) | 0.500 | |
| CT | 26 (49.1) | 44 (50.6) | 0.90 (0.35-02.30) | 0.819 | |
| 44 (41.5) | 78 (44.8) | reference | |||
| 62 (58.5) | 92 (52.9) | 0.84 (0.51-1.37) | 0.477 | ||
| rs461473 | GG | 52 (98.1) | 84 (96.6) | reference | |
| GA | 1 (1.9) | 2 (2.3) | 1.24 (0.11-14.00) | 0.863 | |
| 105 (99.1) | 170 (97.7) | reference | |||
| 1 (0.9) | 2 (1.1) | 1.24 (0.11-13.99) | 0.864 | ||
| rs622342 | AA | 33 (62.3) | 48 (55.2) | reference | |
| CC | 3 (5.7) | 12 (13.8) | 4.13 (0.87-19.65) | 0.075 | |
| CA | 18 (34.0) | 26 (29.9) | 0.99 (0.472.10) | 0.985 | |
| 84 (79.2) | 122 (70.1) | reference | |||
| 22 (20.8) | 50 (28.7) | 1.56 (0.88-2.78) | 0.113 | ||
| rs6265 | CC | 53 (100.0) | 86 (98.9) | monomorphic | monomorphic |
| C | 106 (100.0) | 172 (98.9) | – | – | |
| rs8192675 | CC | 42 (79.2) | 58 (66.7) | reference | |
| TT | 1 (1.9) | 3 (3.4) | 2.17 (0.22-21.62) | 0.508 | |
| CT | 9 (17.0) | 25 (28.7) | 2.01 (0.85-4.75) | 0.111 | |
| 93 (87.7) | 141 (81.0) | reference | |||
| 11 (10.4) | 31 (17.8 | 1.86 (0.89-3.88) | 0.099 |
OR: odds ratio; 95% CI: 95% confidence interval.
Percent does not account for missing allele(s) at specific loci.