Table 4.
Genotype and allele frequencies of four single nucleotide polymorphism(s) demonstrating no significant association to type 2 diabetes mellitus treatment response.
| Unadjusted | Adjusted | |||||||
|---|---|---|---|---|---|---|---|---|
| SNP | Genotype/ Allele | Controlled n (%) | Uncontrolled n (%) | OR (95% CI) | p Values | OR (95% CI) | p Values | Bonferonni Corrected p Values |
| rs316009 | CC | 45 (84.9) | 83 (95.4) | reference | reference | |||
| CT | 8 (15.1) | 3 (0.03) | 0.20 (0.05-0.81) | 0.023 | 0.31 (0.05-0.190) | 0.204 | – | |
| 98 (92.5) | 169 (97.1) | reference | reference | |||||
| 8 (0.08) | 3 (0.02) | 0.22 (0.06-0.84) | 0.027 | 0.85 (0.01-0.93) | 0.044 | 0.088 | ||
| rs316019 | CC | 41 (77.4) | 77 (88.5) | reference | reference | |||
| AA | 1 (0.02) | 0 (0.0) | 0.18 (0.01-4.48) | 0.295 | ||||
| CA | 11 (20.8) | 8 (0.09) | 0.39 (0.14-1.04) | 0.059 | ||||
| C | 93 (87.7) | 162 (93.1) | reference | reference | ||||
| A | 13 (12.3) | 8 (0.05) | 0.35 (0.14-0.8) | 0.026 | 0.72 (0.21-2.44) | 0.593 | – | |
| rs4810083 | CC | 16 (30.2) | 33 (37.9) | reference | reference | |||
| TT | 10 (18.9) | 32 (36.9) | 1.55 (0.61-3.92) | 0.353 | 1.24 (0.42-3.60) | 0.698 | – | |
| CT | 27 (35.7) | 21 (43.1) | 0.38 (0.17-0.86) | 0.021 | 2.80 (1.01-7.79) | 0.049 | 0.098 | |
| 59 (55.7) | 75 (43.1) | reference | reference | |||||
| 47 (44.3) | 97 (55.7) | 1.62 (1.00-2.64) | 0.051 | 0.81 (0.48-1.36) | 0.423 | – | ||
| rs578427 | TT | 10 (18.9) | 15 (17.2) | reference | reference | |||
| CC | 4 (7.5) | 28 (32.2) | 4.67 (1.25-17.44) | 0.022 | 1.80 (0.58-5.64) | 0.312 | ||
| CT | 39 (73.6) | 43 (49.4) | 0.74 (0.30-1.83) | 0.507 | 1.70 (0.45-2.55) | 0.884 | ||
| T | 47 (44.3) | 73 (42.0) | reference | reference | ||||
| C | 59 (55.7) | 99 (56.9) | 1.08 (0.66-1.76) | 0.765 | 1.31 (0.78-2.22) | 0.308 | – | |
OR: odds ratio; 95% CI: 95% confidence interval.
Percent does not account for missing allele(s) at specific loci. Significant p values (<0.05) are bold.